Reference and Bibtex for Networks in molecular evolution by Schuster, P. et. al.

@misc{ schuster02networks,
  author = {P. Schuster and P. Stadler},
  title = {Networks in molecular evolution},
  journal ={Complexity},
  volume={8},
  pages={34--42},
  year = {2002},
  url = {http://citeseer.ist.psu.edu/schuster02networks.html},
ee={http://citeseer.ist.psu.edu/rd/0%2C598572%2C1%2C0.25%2CDownload/http://citeseer.ist.psu.edu/cache/papers/cs/29378/http:zSzzSzwww.tbi.univie.ac.atzSzpaperszSzAbstractszSz02-pks-003.pdf/schuster02networks.pdf}
}

Associated URL:
  http://citeseer.ist.psu.edu/schuster02networks.html
Electronic Edition:
  http://citeseer.ist.psu.edu/rd/0%2C598572%2C1%2C0.25%2CDownload/http://citeseer.ist.psu.edu/cache/papers/cs/29378/http:zSzzSzwww.tbi.univie.ac.atzSzpaperszSzAbstractszSz02-pks-003.pdf/schuster02networks.pdf
Language:
  en
Type:
  misc
Title:
  Networks in molecular evolution
Author:
  Schuster, P. et. al.
Topic:
  Science / Biology / Molecular
Rating:
  4
Comment:

properties of the RNA map were derived:
"For sequence spaces of chain lengths n > 10 there are orders of magnitude more sequences than structures and hence, the map is many-to-one (as predicted analytically above)."
"Few common and many rare structures."
"In other words, for each arbitrarily chosen pair of structures there will be at least on sequence that can form both."

Very general but nice conclusion: 
"We have discussed here only four classes of the networks which play a central role in molecular biology.
Networks of gene regulation, both at level of the
single cell and the signaling networks of multicellular organisms are just as important. In higher organisms neural networks form an additional layer of complexity (see Olaf Sporn's contribution in this issue).
While we begin to understand structure and function of networks within each class, for which ample data are available at least in some cases, little is known on the interaction of the various levels. The mechanisms governing crosstalk between hierarchical levels are, nevertheless, equally important if not more relevant for proper
functioning of organisms. They are in the center of topdown control and regulation, without which every form of organization is doomed to break down. What makes this type of control tricky in but not only in biology is the partial autonomy of agents at the lower level. More and more detailed knowledge on communication between cells will help us to explore successfully the subtle interplay
between local independence and global control."

Acquired:
2006-03-06

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